ABSTRACT
Background and Objective: Iron oxide nanoparticles, including nanoparticles is important in industry and medicine. Nanoparticles affect on detoxification of environmental pollutants such as Pesticides and chlorinated organic solvents.This study was done to evaluate the short term effect of Fe2NiO4 composite nanoparticle on kidney function indeces in wistar rats
Methods: In this experimental study, Twenty four Wistar rat were randomly allocated into three groups, including: control, treated groups 1 and 2. Animales in control, treated groups 1 and 2 were received 0.5cc of saline, 0.5cc of solution containing 100, 200 ppm Fe2NiO4 for 7 days, respectively. Uric acid, ceratinine and urea [BUN] were measured at day 2, 7 and 14
Results: BUN level in treated groups 1 and 2 significantly reduced in comparison with control group at day 7, 14 after intervention [P<0.05]. Uric acid level in treated groups 1 and 2 significantly increased at day 7 and 14. 2 week after intervention, the mean creatinine levels in treated group 2 group significantly reduced in compare to the in treated group 1 and controls [P<0.05]
Conclusion: It seems that the application of Fe2NiO4 nanoparticles in biological system has no toxic effect on the kidney function indeces
ABSTRACT
The increase in the blood concentration of lipids after meals has a significant effect on induction of atherosclerosis. Vaccinium myrtilus has an antioxidant activity, and in this study, we aimed to determine the effects of this plant on atherosclerosis risk factors. In an experimental study, 24 male New Zealand rabbits were randomly designated into three groups of 8 rabbits: Group 1, normal diet; Group 2, a diet containing 1% cholesterol; and Group 3, a diet containing 1% cholesterol and 2% Vaccinium myrtilus powder. The blood glucose, total cholesterol [TC], triglyceride [TG], apolipoprotein B [ApoB], Alanine aminotransferase [ALT], Aspartate aminotransferase [AST], LDL-C [low density lipoprotein], nitrite, nitrate, fibrinogen, and factor VII, which are considered as atherosclerosis risk factors, were measured before the experiment and 3 hours after feeding. The data were analyzed using One-Way Analysis of ANOVA. The P-values below 0.05 [P<0.05] were considered as significant. Consumption of Vaccinium myrtilus significantly decreased the concentrations of LDL-C, TC, aminotransaminases [AST, ALT], ApoB, and fibrinogen compared to the hyper-cholesterolemic diet group [P<0.05]. However, there were no significant differences was found between the group taking Vaccinium myrtilus and hyper-cholesterolemic diet group with regard to the serum glucose, TG, factor VII, nitrite, and nitrate [P>0.05]. The results of this study show that acute consumption of Vaccinium myrtilus might have a protective effect on some atherosclerosis risk factors
ABSTRACT
Metabolic changes in postprandial stage, especially after consumption of high fat meal cause atherosclerosis and increase the risk of cardiovascular diseases. Apple cider vinegar is an acidic juice with useful medicinal effects. In this research; we investigated acute effects of apple cider vinegar intake on some of the biochemical atherosclerosis risk factors in high cholesterol fed rabbits. Thirty two male New Zealand rabbits were randomly divided into four groups: normal diet group, high cholesterol diet group [%1cholesterol],%1 cholesterol with 5ml apple cider vinegar group,%1 cholesterol with 10ml apple cider vinegar group. The C-Reactive Protein [CRP], low density lipoprotein [LDL-C], high density lipoprotein [HDL-C], total cholesterol [TC], malondialdehyde [MDA], oxidized-LDL [OxLDL], serum glutamic pyruvic transaminase [SGPT], serum glutamic oxaloacetate transaminase [SGOT], nitrite, nitrate, glucose, fibrinogen triacylglycerol [TG], apolipoprotein A [ApoA1], apolipoprotein B [ApoB100] were all measured before the experiment and three hours after feeding with these treatment diets. In high cholesterol diet fibrinogen, nitrite, glucose, OxLDL, MDA and CRP showed a significant increase compared to normal diet. Significant differences were observed between both groups of apple cider vinegar by fibrinogen in comparison with hypercholesterolemic diet. Using 10ml apple cider vinegar with cholesterolemic diet caused a significant reduction in Ox-LDL, MDA and glucose in comparison with hypercholesterolemic diet. Moreover, the consumption of 5ml apple cider vinegar with cholesterolemic diet caused a significant decrease in LDL-C and TC compared to hypercholesterolemic diet. No significant difference was found between apple cider vinegar taking groups and hypercholesterol diet in CRP, TG ApoA, HDL-C, ApoB, SGOT, SGPT, nitrite and nitrate. The results showed that acute consumption of apple cider vinegar [as an antioxidant] causes significant reduction on some risk factors of atherosclerosis